4,5-DIFLUORO-2-NITROANILINE 99% CAS NO.78056-39-0

Disperse dyes synthesized from it or its derivatives have significant advantages. This is because introducing a cyanide group adjacent to the amino group can improve the electron withdrawing ability and tolerance of the molecule, generally by 1-2 levels, and the cyanide group has a greater dark effect.

synthetic method

Add methanol ammonia (15mL) to a solution of 1,2,4-trifluoro-5-nitrobenzene (5.00g, 28.0mmol, 1.00 equivalent) in methanol (5mL) and place it in a microwave bottle. Heat the reaction mixture in a microwave at 70 ℃ for 90 minutes. Cool the reaction mixture to room temperature and remove the solvent from the reaction under reduced pressure to obtain the crude product; It was purified by silica gel column chromatography (EtOAc/hexane 1:4). Obtained yellow solid 4,5-difluoro-2-nitroaniline (0.600g, 12.0%). TLC: 30% EtOAc/hexane (Rf: 0.35); 1H NMR (500 MHz, CDCl3): δ 8.00 (t, J=9.0 Hz, 1H), 6.65-6.58 (m, 1H, 6.08 (br s, 2H).

Disperse dyes synthesized from it or its derivatives have significant advantages. This is because introducing a cyanide group adjacent to the amino group can improve the electron withdrawing ability and tolerance of the molecule, generally by 1-2 levels, and the cyanide group has a greater dark effect.